Is Nuclear Factor Erythroid 2–Related Factor 2 Responsible for Sex Differences in Susceptibility to Acetaminophen-Induced Hepatotoxicity in Mice?
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منابع مشابه
Effect of Viola Extract on Acetaminophen-induced Hepatotoxicity in Mice
Introduction: Acetaminophen is a common analgesic that is toxic to the liver in the case of high dose and antioxidants such as herbs can partially inhibit the harmful effects of high dose of such substances. Materials and Methods: In this study, 42 mice weighing 25-30 g were randomly divided into six groups (n=7). The first group as the control group received 1 ml/kg (0.5 ml/kg 12 hours apart)...
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Acetaminophen (APAP) is a widely available antipyretic and analgesic; however, overdose of the drug inflicts severe damage to the liver. It is well established that the hepatotoxicity of APAP is initiated by formation of a reactive metabolite, N‑acetyl‑p‑benzoquinone imine (NAPQI), which can be detoxified by conjugation with reduced glutathione (GSH), a typical antioxidant. We recently found th...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2014
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.114.059006